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Our laboratory is working on understanding how nerve systems (peripheral (e.g sciatic and vagus nerves) or central (brain)) sense and use nutrients (with a special interest for fat -either dietary or secreted by the gut microbiota (bacteria that lives in our gut)-). We know that this sensing is important for i) proper central control of energy balance and cognition, and ii) for proper peripheral nerve system function. Others and we found that this ‘’fat sensing’’ by nerve systems is altered in Aging and when Western-diet is consumed leading to overweight, type II Diabetes and pain. Our research goal is to use in vivo cell-specific mouse model and ex-vivo nerve system cultures (e.g brain slices) to unmask pathways leading to hyperphagia, glucose intolerance and pain observed in Obesity (and metabolic syndrome). Our aim is to find targets to decrease bodyweight, improve insulin sensitivity and peripheral pain. We strive to test interventions on Obese mice cohorts and to understand the molecular signatures underlying the improvement.

 

NEWS

Congratulation to Raiza, PhD student, for her award (Best oral presentation) at PNS2019 ! Nicely Done !

Talk : ”Gut Microbiome and its Role in Obesity-Induced Allodynia

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Poster : ”Schwann Cell- and Neuronal- Specific Translatome in Western-Diet Induced Allodynia Mouse Model

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Screen Shot 2019-03-17 at 7.33.37 AMCongrats Raiza for your busy poster session !

Gut Microbioma and Short Chain Fatty Acids in Obesity-related pain

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February 2019

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–CONGRATULATION Chaitanya for obtaining a Keystone Scholarship !!! Well done ! 

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August 2018

Yay ! We (Dr Aubert, Dr Dugas and Dr Germanwala) received the competitive Collaborative grant again to continue our exciting work on microbiome and pain in Obesity in mice, human nerves and public health.

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October 2018

——-Check our paper ! How Westernized-diet can lead to pain and Targeting neuronal lipid metabolism may be an alternative to addictive pain killers !

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JUNE 2018

Come to see us at the ADA meeting where we will be presenting our research !

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JUNE 2017

Welcome to the NeurObesity lab website!

Our interests : Obesity induced neuropathy, Nuclear receptor, in vivo and in vitro Cell specific approaches (cre lox, ribo tag, dreadd..), Neural sensing in obesity

Projects :

 

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The microbiome Short chain fatty acids and the peripheral nerve system (gut brain communication and impact of microbiome on PNS)

3. Metabolic regulation of receptor trafficking in the hypothalamus

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Next events :

—We will present at : 

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  —-St Albert day @ Loyola , research day,  November 3rd

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